The Megapack of Organic & Vegan Betwelve – 365 tablets

You asked for it, we did it: the 365-tablet pack of apple-flavoured Betwelve is finally here! 

An ideal format for families provides a daily supplement of 3 months for 4 people. It can also be used to refill our famous eco-friendly containers with their cork lid.

If you haven’t noticed yet, our natural origin active form vitamin B12 is particularly suitable for vegetarian and vegan diets.

Taking a tablet is not always something we like doing… but don’t panic, we have thought of everything, this Megapack contains 365 tablets with a delicious apple flavour – perfect for all the family.

And so that you can indulge yourself and discover the rest of our range:
🎁 postage is free is free on orders of 3 or more items

🚚 Delivery in 3 to 5 working days

Does not replace a varied and balanced diet or a healthy lifestyle. Do not exceed the recommended daily dose.
Keep out of reach of young children.



An environmentally friendly and money saving packaging!

We designed our famous containers in recycled cardboard to be ideal for an economical refill system.

After several months of R&D the Mega Pack was born!

With its 365 tablets it:

  • provides a three-month supply for a family of four
  • allows proper storage of your Betwelve
    OR enables to refill a Bio Frères reusable container 3 times

And the best thing about it is that it will save you money, it costs 10€ less than buying 3 separate 90-tablet packs.

Not bad hey?

And what about Betwelve?

vitamin b12 allegations

vitamin b12 allegations

B12 (Cobalamin for scientists or Betwelve for friends) is a vitamin that is essential for the normal formation of red blood cells, for the proper functioning of the nervous system and that helps reduce fatigue. It is produced by a process of bacterial fermentation which takes place mainly in cattle. It is then found in the meat consumed by humans with an omnivorous diet (i.e. meat eaters).

As humans are not able to produce this B12, if they wish to adopt a vegetarian or vegan diet they must find other sources of B12 to avoid deficiencies.

Luckily for us, since the 1970s, researchers have succeeded in recreating the conditions for bacterial fermentation in the laboratory (which occurs naturally in ruminants) making possible the synthesis of B12, also known as cyanocobalamin. So, since then, it has been possible to stay healthy by supplementing with B12 without eating fresh meat and selling one’s vegan soul to the butcher. Unfortunately, this cyanocobalamin is synthesized. It is therefore not natural and is manufactured in a laboratory.

Of course, with a name like BIO Frères (Organic Brothers), we’re not really much of a fan….

But wait, there is something new:

Betwelve our natural vitamin B12

Fortunately, there are now natural bacterial fermentation processes that produce Betwelve! Ours is therefore the result of a natural fermentation on a bed of our dear friends, the organic Shiitake mushroom… And bang, natural vitamin B12!

Our organic Shiitake powder contains a cocktail of 3 natural forms:

  • Hydroxycobalamin which is not bioactive, but only needs 3 transformations to become so (it is therefore better than Cyanocobalamin),
  • Methylcobalamin and Adenosylcobalamin which are bioactive and can therefore be used directly by the body.

We have put this organic-trio in tablets that we have designed with a recipe that contains as few ingredients as possible. For example, we have chosen a formula without silicon dioxide.

We take care to test each batch of tablets to ensure that they are always microbiologically safe.

If you have any doubts, or have heard that naturally occurring forms are not effective, we invite you to read our full article on the subject.

How to supplement with B12?

The European Food Safety Authority (ESFA) recommends 4µg (micrograms) for vitamin B12 for adults.  Unfortunately, this recommended amount does not take into account problems with absorption that come into play when taking food supplements. So supplementing with 4µg of vitamin B12 every day is not enough to prevent deficiency (otherwise it would be too easy).

We’ve packed our tablets with 25µg of B12 (625% of the reference intake) to make sure your body gets everything it needs every day and you stay healthy. Don’t worry, there is no maximum daily dose for B12, once your body has what it needs, it simply eliminates the rest and everyone is happy.

So just take 1 tablet a day in the middle of a meal – chew well or let it dissolve – to reach the recommended RDA. Great no ?

To find out much, much more about vitamin B12 and the science behind it:

Vitamin B12 : the complete guide

Simple ingredients


b12 megapack apple ingredients

b12 megapack apple ingredients

We have carefully chosen organic ingredients to obtain tasty vitamin B12 chewable tablets:

  • Organic dextrose for a bit of crunch
  • Organic acacia gum & magnesium carbonate and silicate for a nice texture
  • Organic Shiitake powder (Lentinus edodes) which contains the secret of our natural B12 in the active forms Adenosyl, Hydroxy and Methylcobalamin
  • natural flavouring

Order your Megapack of Betwelve